Design in the dark – REFiL sheds light on fragment-based drug discovery


The ARC CFBD aims to advance the techniques and workflows of fragment-based drug design to establish new avenues for drug discovery. Our team have used our novel workflow called REFiL (Rapid Elaboration of Fragments into Leads) to demonstrate accelerated development of leads for drug discovery. This new method has the potential to produce a drastic … Continue reading Design in the dark – REFiL sheds light on fragment-based drug discovery

ARC CFBD researcher awarded Early Career Research Grant by AINSE


Dr Anitha Kopinathan was awarded an Early Career Researcher Grant by The Australian Institute of Nuclear Science and Engineering (AINSE). AINSE boosts the capability of Australia and New Zealand in nuclear science, engineering and related research field by facilitating collaboration, education and training. The Early Career Researcher Grant provides a single payment of A$10,000 to … Continue reading ARC CFBD researcher awarded Early Career Research Grant by AINSE

REFiL, binding affinity and BRD3-ET


Latest research from the Centre, Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain, published in ChemRxiv, March 2020. The research team use an integrated workflow for the Rapid Elaboration of Fragments into Leads (REFiL) that provides a systematic approach to generate higher-affinity binders without the need for structural information. Adams, L. … Continue reading REFiL, binding affinity and BRD3-ET

Benzofuran hit into new class of EcDsbA inhibitors


The research paper, The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors, was published in Molecules, October 2019. The work takes a fragment-based drug discovery approach to target the thiol-disulfide oxidoreductase enzyme DsbA from Escherichia coli (EcDsbA). It suggests the potential to develop benzofuran fragments into a novel class of EcDsbA inhibitors. Duncan, … Continue reading Benzofuran hit into new class of EcDsbA inhibitors

VR app for teaching biochem students


New research, Peppy: A virtual reality environment for exploring the principles of polypeptide structure, published in Protein Science, 2020. Joel Mackay (USYD) and collaborators built a virtual reality application, ‘Peppy’ aimed at facilitating teaching of the principles of protein secondary structure to undergraduate biochemistry students. Research findings on the implementation and use of Peppy, as … Continue reading VR app for teaching biochem students