Dr Narelle Tunstall, Centre Manager The Centre for Fragment-Based Design officially commenced on 22 July 2019 with the execution of our Participants Agreement and the Centre was launched by The Honourable Kevin Andrews MP on 12 November 2019. The launch was held in conjunction with Australia’s national conference on Fragment-Based Drug Design, which allowed us … Continue reading Celebrating the official launch of ARC CFBD
Latest research from the Centre, Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain, published in ChemRxiv, March 2020. The research team use an integrated workflow for the Rapid Elaboration of Fragments into Leads (REFiL) that provides a systematic approach to generate higher-affinity binders without the need for structural information. Adams, L. … Continue reading REFiL, binding affinity and BRD3-ET
The research paper, The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors, was published in Molecules, October 2019. The work takes a fragment-based drug discovery approach to target the thiol-disulfide oxidoreductase enzyme DsbA from Escherichia coli (EcDsbA). It suggests the potential to develop benzofuran fragments into a novel class of EcDsbA inhibitors. Duncan, … Continue reading Benzofuran hit into new class of EcDsbA inhibitors
New research, Peppy: A virtual reality environment for exploring the principles of polypeptide structure, published in Protein Science, 2020. Joel Mackay (USYD) and collaborators built a virtual reality application, ‘Peppy’ aimed at facilitating teaching of the principles of protein secondary structure to undergraduate biochemistry students. Research findings on the implementation and use of Peppy, as … Continue reading VR app for teaching biochem students
Three Minute Thesis (3MT) Asia-Pacific A HUGE congratulations to our very own Beatrice Chiew who is this years Monash 3MT winner and a Top 10 finalist of the 3MT Asia-Pacific final! This is a fantastic achievement and we are incredibly proud of her, her research and her amazing sci-com skills! Watch her Asia-Pacific final presentation here.
Martin Scanlon is the Director of the ARC CFBD and his research group is based at Monash Institute of Pharmaceutical Sciences (Parkville campus). Members of the Scanlon group were dragged out of their labs and offices to update the group photo recently… we have a few openings in the back row… do you want to … Continue reading Meet the Scanlon group