We are a team of multidisciplinary experts in Fragment-Based Design. Our research is underpinned by four research themes:

Fragment Elaboration

Developing and optimising systematic approaches to selecting suitable fragments for development and enhancement into potent leads (REFiL)

Fragment Library Design

Developing libraries of chemical fragments to cover chemical space and potentially uncover new and valuable bioactive molecules

Fragment Screening

Optimising biophysical screening methods (NMR, MS) and fragment hit ranking strategies to identify compounds that bind to a target protein & accelerate lead development

Protein Expression and Sample Preparation

Developing new approaches to sample preparation and screening to enable FBD for larger, more complex and membrane-bound proteins