The projects within the Centre will accelerate research translation and industry engagement by providing a strategy for the screening of a biological target and early medicinal chemistry to elaborate small fragments into more potent compounds.

Microscale parallel synthesis

Enabling fragment-based lead discovery for challenging targets

Cubane as a 3D scaffold for fragment library construction

Developing and optimising chemical elaboration (REFiL) of fragments into potent leads

Finding inhibitors of antivirulence targets

Characterisation of soluble and membrane proteins for fragment-based drug discovery

Identifying Hit Fragments using Mass Spectrometry

SPR method development for fragment-based design