Headquartered at Monash Institute of Pharmaceutical Sciences, the ARC CFBD brings together key academic institutions and their state-of the art infrastructure; Monash Fragment Platform, Griffith University Institute for Drug Discovery, The University of Sydney Drug Discovery Initiative, with industry research partners who have clear pathways for research translation.
Fragment Library Design
Developing libraries of chemical fragments to cover chemical space and potentially uncover new and valuable bioactive molecules
Optimising biophysical screening methods (NMR, MS) and fragment hit ranking strategies to identify compounds that bind to a target protein & accelerate lead development
Protein Expression & Sample Preparation
Developing new approaches to sample preparation and screening to enable FBD for larger, more complex and membrane-bound proteins
Developing and optimising systematic approaches to selecting suitable fragments for development and enhancement into potent leads (REFiL)