This research was funded (partially or fully) by the Australian Government through the Australian Research Council.
2020
| Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme Kaczmarski JA, Mahawaththa MC, Feintuch A, Clifton BE, Adams LA, Goldfarb D, Otting G & Jackson CJ View research paper here |
| Cyclic peptides can engage a single binding pocket through highly divergent modes Patel K, Walport LJ, Walshe JL, Solomon PD, Low JKK, Tran DH, Mouradian KS, Silva APG, Wilkinson-White L, Norman A, Franck C, Matthews JM, Guss JM, Payne RJ, Passioura T, Suga H, Mackay JP View research paper here |
| Personal Accounts of Australian Drug Discovery at the Public–Private Interface Baell J View research paper here |
| Investigation of thiazolyl–benzothiophenamides as potential agents for African sleeping sickness Brown RW, Abdel-Megeed AM, Keller PA, Jones AJ, Sykes ML, Kaiser M, Baell J, Avery VM, Hyland CJT View research paper here |
| A novel purification procedure for active recombinant human DPP4 and the inability of DPP4 to bind SARS-CoV-2 Xi CR, Di Fazio A, Nadvi NA, Patel K, Xiang MSW, Zhang HE, Deshpande C, Low JKK, Wang XT, Chen Y, Osborne B, Vieira de Ribeiro AJ, McCaughan GW, Church WB, Mackay JP, Gorrell MD View research paper here |
| NMR in pharmaceutical discovery and development Norton RS, Jahnke W View research paper here |
| NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei Nebl S, Alwan WS, Williams ML, Sharma G, Taylor A, Doak BC, Wilde KL, McMahon RM, Halili MA, Martin JL, Capuano B, Fenwick RB, Mohanty B, Scanlon MJ View research paper here |
| The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides Tajti G, Wai DCC, Panyi G, Norton RS View research paper here |
| Improving membrane permeation in the beyond rule-of-five space by using prodrugs to mask hydrogen bond donors Barlow N, Chalmers DK, Williams-Noonan BJ, Thompson PE, Norton RS View research paper here |
| The novel P2X7 receptor antagonist PKT100 improves cardiac function and survival in pulmonary hypertension by direct targeting of the right ventricle Hansen T, Karimi Galougahi K, Besnier M, Genetzakis E, Tsang M, Finemore M, O’Brien-Brown J, Di Bartolo BA, Kassiou M, Bubb KJ, Figtree GA View research paper here |
| Rapid elaboration of fragments into leads by X-ray crystallographic screening of parallel chemical libraries (REFiLx) Bentley MR, Ilyichova OV, Wang G, Williams ML, Sharma G, Alwan WS, Whitehouse RL, Mohanty B, Scammells PJ, Heras B, Martin JL, Totsika M, Capuano B, Doak BC, Scanlon MJ View research paper here |
| A structurally minimized yet fully active insulin based on cone-snail venom insulin principles Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH View research paper here |
| Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides McNamara N, Rahmani R, Sykes ML, Avery VM, Baell J View research paper here |
| Modulation of lymphocyte potassium channel KV1.3 by membrane-penetrating, joint-targeting immunomodulatory plant defensin Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG View research paper here |
| Structure–activity relationship study reveals the molecular basis for specific sensing of hydrophobic amino acids by the Campylobacter jejuni chemoreceptor Tlp3 Khan MF, Machuca MA, Rahman MM, Koç C, Norton RS, Smith BJ, Roujeinikova A View research paper here |
| Rapid elaboration of fragments into leads applied to Bromodomain-3 extra terminal domain Adams LA, Wilkinson-White LE, Gunzburg MJ, Headey SJ, Scanlon MJ, Capuano B, Mackay JP, Doak BC View research paper here | Read blog post here |
2019
| The fragment-based development of a benzofuran hit as a new class of Escherichia coli DsbA inhibitors Duncan L, Wang G, Ilyichova OV, Scanlon MJ, Heras BM, Abbott B View research paper here |
| A virtual reality environment for exploring the principles of polypeptide structure Doak DG, Denyer GS, Gerrard JA, Mackay JP, Allison JR View research paper here |
| The stoichiometry and interactome of the Nucleosome Remodeling and Deacetylase (NuRD) complex are conserved across multiple cell lines Tabar MS, Mackay JP, Low JKK View research paper here |
