This research was funded (partially or fully) by the Australian Government through the Australian Research Council.

2020

NMR in pharmaceutical discovery and development
Norton, R.S.; Jahnke, W.
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NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei
Nebl, S.; Alwan, W. S.; Williams, M. L.; Sharma, G.; Taylor, A.; Doak, B. C.; Wilde, K. L.; McMahon, R. M.; Halili, M. A.; Martin, J. L.; Capuano, B.; Fenwick, R. B.; Mohanty, B.; Scanlon, M. J.
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Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoreceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive
Mathiew, M.; Dennis, B.; Bennetts, F.; Su, E.; Nguyen, N.; Botteon, A.; Baell, J.; Ventura, S.
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The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides
Tajti, G.; Wai, D. C. C.; Panyi, G.; Norton, R. S.
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Improving membrane permeation in the beyond rule-of-five space by using prodrugs to mask hydrogen bond donors
Barlow, N.; Chalmers, D. K.; Williams-Noonan, B. J.; Thompson, P. E.; Norton, R. S.
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The novel P2X7 receptor antagonist PKT100 improves cardiac function and survival in pulmonary hypertension by direct targeting of the right ventricle
Hansen, T.; Karimi Galougahi, K.; Besnier, M.; Genetzakis, E.; Tsang, M.; Finemore, M.; O’Brien-Brown, J.; Di Bartolo, B. A.; Kassiou, M.; Bubb, K. J.; Figtree, G. A.
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Rapid elaboration of fragments into leads by X-ray crystallographic screening of parallel chemical libraries (REFiLx)
Bentley, M. R.; Ilyichova, O. V.; Wang, G.; Williams, M. L.; Sharma, G.; Alwan, W. S.; Whitehouse, R. L.; Mohanty, B.; Scammells, P. J.; Heras, B.; Martin, J. L.; Totsika, M.; Capuano, B.; Doak, B. C.; Scanlon, M. J.
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A structurally minimized yet fully active insulin based on cone-snail venom insulin principles
Xiong, X.; Menting, J. G.; Disotuar, M. M.; Smith, N. A.; Delaine, C. A.; Ghabash, G.; Agrawal, R.; Wang, X.; He, X.; Fisher, S. J.; MacRaild, C. A.; Norton, R. S.; Gajewiak, J.; Forbes, B. E.; Smith, B. J.; Safavi-Hemami, H.; Olivera, B.; Lawrence, M. C.; Chou, D. H.
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Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides
McNamara, N.; Rahmani, R.; Sykes, M. L.; Avery, V. M.; Baell, J.
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Modulation of lymphocyte potassium channel KV1.3 by membrane-penetrating, joint-targeting immunomodulatory plant defensin
Ong, S. T.; Bajaj, S.; Tanner, M. R.; Chang, S. C.; Krishnarjuna, B.; Ng, X. R.; Morales, R. A. V.; Chen, M. W.; Luo, D.; Patel, D.; Yasmin, S.; Ng, J. J. H.; Zhuang, Z.; Nguyen, H. M.; El Sahili, A.; Lescar, J.; Patil, R.; Charman, S. A.; Robins, E. G.; Goggi, J. L.; Tan, P. W.; Sadasivam, P.; Ramasamy, B.; Hartimath, S. V.; Dhawan, V.; Bednenko, J.; Colussi, P.; Wulff, H.; Pennington, M. W.; Kuyucak, S.; Norton, R. S.; Beeton, C.; Chandy, K. G.
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Structure–activity relationship study reveals the molecular basis for specific sensing of hydrophobic amino acids by the Campylobacter jejuni chemoreceptor Tlp3
Khan, M. F.; Machuca, M. A.; Rahman. M. M.; Koç, C.; Norton, R. S.; Smith, B. J.; Roujeinikova, A.
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Rapid elaboration of fragments into leads applied to Bromodomain-3 extra terminal domain
Adams, L. A.; Wilkinson-White, L. E.; Gunzburg, M. J.; Headey, S. J.; Scanlon, M. J.; Capuano, B.; Mackay, J. P.; Doak, B. C.
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2019

The fragment-based development of a benzofuran hit as a new class of Escherichia coli DsbA inhibitors
Duncan, L.; Wang, G.; Ilyichova, O. V.; Scanlon, M. J.; Heras, B. M.; Abbott, B.
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A virtual reality environment for exploring the principles of polypeptide structure
Doak, D. G.; Denyer, G. S.; Gerrard, J. A.; Mackay, J. P.; Allison, J. R.
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The stoichiometry and interactome of the Nucleosome Remodeling and Deacetylase (NuRD) complex are conserved across multiple cell lines
Tabar, M. S.; Mackay, J. P.; Low, J. K. K.
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