Congratulations to PhD student Karoline Sanches from Monash University who published a paper as first author. The paper was published in Toxicon in October 2021.
Conformational dynamics in peptide toxins: Implications for receptor interactions and molecular design
Karoline Sanchesa,b,1, Dorothy C.C. Waia,1, Raymond S. Nortona,b aMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia bARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria, 3052, Australia 1These authors contributed equally
Peptide toxins are often potent and selective blockers of ion channels and are therefore of significant interest to the pharmaceutical and biotech industries. For example, an analogue of the sea anemone peptide ShK, which targets the voltage-gated potassium channel Kv1.3, is currently in clinical trials for the treatment of autoimmune disorders. Studying the structure-function relationship and the dynamics of these peptides is pivotal to understanding their binding to receptors, as well as to designing new drugs. In this article, we highlight the important contribution of NMR to characterising peptide toxin dynamics. It is shown that even disulphide-rich peptides display dynamics in various timescales, the characterisation of which through NMR is crucial for understanding their receptor interactions.
Dr Narelle Tunstall began in February 2019 as Manager of the ARC Centre for Fragment-Based Design.
Narelle has a PhD in genetics from Monash University (2007), and research management experience across 6 Australian Universities which includes management of two ARC Training Centres, an NHMRC Centre for Clinical Research Excellence and a Commonwealth funded Collaborative Research Network.
More recently, she has been a Manager of Researcher Development, where she has developed training programs for Graduate and Early Career Researchers and she is currently training as a Career Development Practitioner with the aim of providing Career Guidance to PhD graduates.
Narelle is passionate about supporting researchers, their projects, and their careers, to ultimately support research outcomes.