Latest research from the Centre, Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain, published in ChemRxiv, March 2020.

The research team use an integrated workflow for the Rapid Elaboration of Fragments into Leads (REFiL) that provides a systematic approach to generate higher-affinity binders without the need for structural information.

Adams, L. A., Wilkinson-White, L. E., Gunzburg, M. J., Headey, S. J., Scanlon, M. J., Capuano, B., Mackay, J. P., and Doak, B. C. Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain. ChemRxiv. 2020. 10.26434/chemrxiv.12026952